| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 2003 | 10/24 | Blacksburg | 28 | 48 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Stephen Magenbauer | ||||
| 2004 | 10/29 | Blacksburg | 0 | 19 | L | 1 | Away | Blacksburg | Bill Brown Stadium | J. R. Edwards | ||||
| 2005 | 10/28 | Blacksburg | 21 | 27 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | J. R. Edwards | ||||
| 2006 | 10/27 | Blacksburg | 13 | 3 | W | 1 | Away | Blacksburg | Bill Brown Stadium | J. R. Edwards | ||||
| 2007 | 11/2 | Blacksburg | 14 | 52 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | J. R. Edwards | ||||
| 2008 | 10/31 | Blacksburg | 26 | 20 | W | 1 | Away | Blacksburg | Bill Brown Stadium | J. R. Edwards | ||||
| 2009 | 10/9 | Blacksburg | 24 | 6 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2010 | 10/8 | Blacksburg | 14 | 30 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2011 | 10/7 | Blacksburg | 41 | 7 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2012 | 10/5 | Blacksburg | 13 | 10 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2013 | 10/11 | Blacksburg | 20 | 3 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2014 | 10/10 | Blacksburg | 13 | 7 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2015 | 10/1 | Blacksburg | 37 | 51 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2016 | 9/30 | Blacksburg | 45 | 44 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2017 | 10/20 | Blacksburg | 18 | 44 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2018 | 10/19 | Blacksburg | 7 | 26 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2019 | 10/25 | Blacksburg | 23 | 29 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2021 | 3/19 | Blacksburg | 22 | 0 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2021 | 10/22 | Blacksburg | 35 | 0 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2022 | 10/21 | Blacksburg | 28 | 7 | W | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2023 | 10/20 | Blacksburg | 30 | 6 | W | 1 | Away | Blacksburg | Bill Brown Stadium | Scott Weaver | ||||
| 2024 | 10/25 | Blacksburg | 7 | 28 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Scott Weaver | ||||
| 2025 | 10/10 | Blacksburg | 0 | 43 | L | 1 | Away | Blacksburg | Bill Brown Stadium | Bud Tolliver | ||||
| 2026 | 10/9 | Blacksburg | 20 | 51 | L | 1 | Home | Roanoke | Dwight Bogle Stadium | Bud Tolliver | ||||
| 499 | 561 | 12 | 12 | 0 | .500 | |||||||||
| 20.79 | 23.38 | -2.58 | ||||||||||||