| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 2005 | 8/26 | Louisville DeSales | 38 | 19 | W | 1 | Home | Lexington | Paul Rains | ||||||
| 2006 | 8/25 | Louisville DeSales | 28 | 10 | W | 1 | Neutral | Louisville | Iroquois High School | Paul Rains | |||||
| 2020 | 9/12 | Louisville DeSales | 24 | 20 | W | 1 | Away | Louisville | Doug Charles | ||||||
| 90 | 49 | 3 | 0 | 0 | 1.000 | ||||||||||
| 30.00 | 16.33 | 13.67 |