| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1908 | Andrew Lewis | 51 | 0 | W | 1 | Home | Roanoke | Bob Williams | ||||||
| 1909 | Andrew Lewis | 10 | 0 | W | 1 | Home | Roanoke | Meisner | ||||||
| 1910 | Andrew Lewis | 5 | 0 | W | 1 | Ernest Sampson | ||||||||
| 1916 | 9/29 | Andrew Lewis | 10 | 0 | W | 1 | Away | Salem | Roanoke College | Robert Marshall | ||||
| 1917 | 10/19 | Andrew Lewis | 7 | 9 | L | 1 | Home | Roanoke | Fairgrounds | Robert Marshall | ||||
| 1920 | 10/16 | Andrew Lewis | 7 | 0 | W | 1 | Away | Salem | Roanoke College | J. H. Fallwell | ||||
| 1921 | 10/29 | Andrew Lewis | 20 | 0 | W | 1 | Home | Roanoke | Fairgrounds | L. L. Davis | ||||
| 1922 | 10/28 | Andrew Lewis | 6 | 0 | W | 1 | Away | Salem | Roanoke College | L. L. Davis | ||||
| 1926 | 10/16 | Andrew Lewis | 14 | 0 | W | 1 | Away | Salem | Roanoke College | Hunk Hurt | ||||
| 1927 | 10/29 | Andrew Lewis | 18 | 6 | W | 1 | Home | Roanoke | Maher Field | Hunk Hurt | ||||
| 1928 | 11/2 | Andrew Lewis | 6 | 0 | W | 1 | Away | Salem | Roanoke College | Hunk Hurt | ||||
| 1929 | 11/16 | Andrew Lewis | 6 | 6 | T | 1 | Home | Roanoke | Maher Field | Hunk Hurt | ||||
| 1930 | 11/15 | Andrew Lewis | 6 | 0 | W | 1 | Away | Salem | Hunk Hurt | |||||
| 1931 | 10/10 | Andrew Lewis | 14 | 7 | W | 1 | Home | Roanoke | Maher Field | Hunk Hurt | ||||
| 1932 | 10/15 | Andrew Lewis | 0 | 0 | T | 1 | Away | Salem | Hunk Hurt | |||||
| 1933 | 10/14 | Andrew Lewis | 6 | 20 | L | 1 | Home | Roanoke | Maher Field | Hunk Hurt | ||||
| 1934 | 10/13 | Andrew Lewis | 7 | 0 | W | 1 | Home | Roanoke | Maher Field | Hunk Hurt | ||||
| 1935 | 10/12 | Andrew Lewis | 20 | 0 | W | 1 | Home | Roanoke | Maher Field | Hunk Hurt | ||||
| 1936 | 10/10 | Andrew Lewis | 7 | 0 | W | 1 | Home | Roanoke | Maher Field | Hunk Hurt | ||||
| 1937 | 10/30 | Andrew Lewis | 2 | 6 | L | 1 | Home | Roanoke | Maher Field | Claude Morman | ||||
| 1938 | 11/6 | Andrew Lewis | 7 | 0 | W | 1 | Home | Roanoke | Maher Field | Claude Morman | ||||
| 1939 | 10/7 | Andrew Lewis | 13 | 6 | W | 1 | Home | Roanoke | Maher Field | Claude Morman | ||||
| 1940 | 10/26 | Andrew Lewis | 7 | 15 | L | 1 | Home | Roanoke | Maher Field | Claude Morman | ||||
| 1941 | 10/25 | Andrew Lewis | 25 | 6 | W | 1 | Home | Roanoke | Maher Field | Rudy Rohrdanz | ||||
| 1942 | 10/24 | Andrew Lewis | 35 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1943 | 10/23 | Andrew Lewis | 27 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Al Boyer | ||||
| 1944 | 10/28 | Andrew Lewis | 21 | 7 | W | 1 | Home | Roanoke | Victory Stadium | Al Boyer | ||||
| 1945 | 10/26 | Andrew Lewis | 25 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Al Boyer | ||||
| 1946 | 10/26 | Andrew Lewis | 0 | 0 | T | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1947 | 10/24 | Andrew Lewis | 22 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1948 | 10/22 | Andrew Lewis | 21 | 14 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1949 | 10/21 | Andrew Lewis | 35 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1950 | 10/27 | Andrew Lewis | 26 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1951 | 10/26 | Andrew Lewis | 14 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1952 | 10/24 | Andrew Lewis | 25 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1953 | 10/23 | Andrew Lewis | 14 | 13 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1954 | 10/22 | Andrew Lewis | 28 | 6 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1955 | 10/28 | Andrew Lewis | 20 | 13 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1956 | 11/20 | Andrew Lewis | 26 | 7 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | postponed from 10-20 | |||
| 1957 | 10/25 | Andrew Lewis | 26 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1958 | 10/24 | Andrew Lewis | 13 | 13 | T | 1 | Home | Roanoke | Victory Stadium | Rudy Rohrdanz | ||||
| 1959 | 10/24 | Andrew Lewis | 43 | 6 | W | 1 | Home | Roanoke | Victory Stadium | Charlie Tucker | ||||
| 1960 | 10/21 | Andrew Lewis | 7 | 0 | W | 1 | Away | Salem | Salem Municipal Stadium | Charlie Tucker | ||||
| 1961 | 10/21 | Andrew Lewis | 0 | 21 | L | 1 | Away | Salem | Salem Municipal Stadium | Joe Downing | postponed | |||
| 1962 | 10/26 | Andrew Lewis | 1 | 0 | W | 1 | Home | Roanoke | Victory Stadium | Bill Benson | forfeit - original score 0-6 | |||
| 1963 | 10/25 | Andrew Lewis | 19 | 28 | L | 1 | Away | Salem | Municipal Stadium | Bill Benson | ||||
| 1964 | 10/23 | Andrew Lewis | 6 | 31 | L | 1 | Home | Roanoke | Victory Stadium | Marshall Ebert | ||||
| 1965 | 10/22 | Andrew Lewis | 13 | 26 | L | 1 | Away | Salem | Municipal Stadium | Hank Hambrick | ||||
| 1966 | 9/23 | Andrew Lewis | 6 | 40 | L | 1 | Home | Roanoke | Victory Stadium | Hank Hambrick | ||||
| 1967 | 9/22 | Andrew Lewis | 0 | 28 | L | 1 | Away | Salem | Salem Municipal Stadium | Hank Hambrick | ||||
| 1968 | 9/28 | Andrew Lewis | 12 | 7 | W | 1 | Home | Roanoke | Victory Stadium | Hank Hambrick | ||||
| 1969 | 9/26 | Andrew Lewis | 22 | 19 | W | 1 | Away | Salem | Municipal Stadium | Hank Hambrick | ||||
| 1970 | 9/26 | Andrew Lewis | 6 | 29 | L | 1 | Home | Roanoke | Victory Stadium | Dave Osborne | ||||
| 1971 | 9/24 | Andrew Lewis | 6 | 21 | L | 1 | Away | Salem | Municipal Stadium | Dave Osborne | ||||
| 1972 | 9/30 | Andrew Lewis | 0 | 41 | L | 1 | Home | Roanoke | Victory Stadium | Dave Osborne | ||||
| 1973 | 9/28 | Andrew Lewis | 29 | 46 | L | 1 | Away | Salem | Salem Municipal Stadium | Dave Osborne | ||||
| 822 | 497 | 38 | 14 | 4 | .714 | |||||||||
| 14.68 | 8.88 | 5.80 |