| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1976 | 11/12 | Whitesburg | 13 | 17 | L | 1 | Home | Prestonsburg | Philip Haywood | playoff at Prestonsburg | ||||
| 1981 | 11/13 | Johns Creek | 27 | 8 | W | 1 | Away | Meta | Philip Haywood | playoff at Meta | ||||
| 1981 | 11/20 | Somerset | 0 | 10 | L | 1 | Away | Somerset | William Clark Field | Philip Haywood | playoff at Somerset | |||
| 1982 | 11/12 | Whitesburg | 26 | 6 | W | 1 | Home | Prestonsburg | Philip Haywood | playoff at Prestonsburg | ||||
| 1982 | 11/19 | Corbin | 0 | 28 | L | 1 | Home | Prestonsburg | Philip Haywood | playoff at Prestonsburg | ||||
| 1983 | 11/4 | M. C. Napier | 20 | 0 | W | 1 | Away | Hazard | Philip Haywood | playoff at Hazard | ||||
| 1983 | 11/11 | Somerset | 0 | 17 | L | 1 | Away | Somerset | William Clark Field | Philip Haywood | playoff at Somerset | |||
| 1984 | 11/3 | Hazard | 14 | 19 | L | 1 | Home | Prestonsburg | Chuke Williams | playoff at Prestonsburg | ||||
| 1985 | 11/8 | Hazard | 47 | 8 | W | 1 | Away | Hazard | Daniel Field | Chuke Williams | playoff at Hazard | |||
| 1985 | 11/15 | Corbin | 27 | 6 | W | 1 | Away | Corbin | Campbell Field | Chuke Williams | playoff at Corbin | |||
| 1985 | 11/23 | Newport Central Catholic | 7 | 20 | L | 1 | Away | Newport | Chuke Williams | playoff at Newport | ||||
| 1989 | 11/10 | Somerset | 0 | 52 | L | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1990 | 11/9 | Corbin | 13 | 47 | L | 1 | Away | Corbin | Campbell Field | Bill Letton | playoff at Corbin | |||
| 1991 | 11/8 | Mason County | 30 | 38 | L | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1992 | 11/6 | Mason County | 29 | 12 | W | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1992 | 11/13 | Russell | 13 | 3 | W | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1992 | 11/20 | Lawrence County | 22 | 8 | W | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1992 | 11/27 | Danville | 6 | 37 | L | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1993 | 11/5 | Lewis County | 54 | 8 | W | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1993 | 11/12 | Lawrence County | 51 | 6 | W | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1993 | 11/19 | Russell | 21 | 0 | W | 1 | Away | Flatwoods | Henry R. Evans Stadium | Bill Letton | playoff at Flatwoods | |||
| 1993 | 11/26 | Danville | 16 | 15 | W | 1 | Away | Danville | Admiral Stadium | Bill Letton | playoff at Danville | |||
| 1993 | 12/3 | Mayfield | 12 | 13 | L | 1 | Neutral | Louisville | Cardinal Stadium | Bill Letton | championship at Louisville | |||
| 1994 | 11/4 | East Carter | 37 | 29 | W | 1 | Home | Prestonsburg | Bill Letton | playoff at Prestonsburg | ||||
| 1994 | 11/11 | Russell | 7 | 14 | L | 1 | Away | Flatwoods | Henry R. Evans Stadium | Bill Letton | playoff at Flatwoods | |||
| 1995 | 11/3 | Russell | 6 | 44 | L | 1 | Away | Flatwoods | Henry R. Evans Stadium | Bill Letton | playoff at Flatwoods | |||
| 1996 | 11/8 | Fleming County | 40 | 6 | W | 1 | Home | Prestonsburg | John Derossett | playoff at Prestonsburg | ||||
| 1996 | 11/15 | Newport | 6 | 49 | L | 1 | Away | Newport | John Derossett | playoff at Newport | ||||
| 1997 | 11/7 | Newport | 26 | 27 | L | 1 | Home | Prestonsburg | John Derossett | playoff at Prestonsburg | ||||
| 1998 | 11/6 | Russell | 28 | 22 | W | 1 | Home | Prestonsburg | John Derossett | playoff at Prestonsburg | ||||
| 1998 | 11/13 | Lawrence County | 14 | 50 | L | 1 | Away | Louisa | John Derossett | playoff at Louisa | ||||
| 1999 | 11/5 | Breathitt County | 12 | 55 | L | 1 | Away | Jackson | John Derossett | playoff at Jackson | ||||
| 2000 | 11/3 | Powell County | 39 | 7 | W | 1 | Home | Prestonsburg | John Derossett | playoff at Prestonsburg | ||||
| 2000 | 11/10 | Middlesboro | 30 | 7 | W | 1 | Home | Prestonsburg | John Derossett | playoff at Prestonsburg | ||||
| 2000 | 11/17 | Breathitt County | 22 | 6 | W | 1 | Home | Prestonsburg | John Derossett | playoff at Prestonsburg | ||||
| 2000 | 11/24 | Boyd County | 8 | 56 | L | 1 | Home | Prestonsburg | John Derossett | playoff at Prestonsburg | ||||
| 2001 | 11/2 | Powell County | 79 | 20 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2001 | 11/9 | Leslie County | 33 | 0 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2001 | 11/16 | Belfry | 34 | 14 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2001 | 11/23 | Mason County | 18 | 13 | W | 1 | Away | Maysville | John Derossett | playoff at Maysville | ||||
| 2001 | 11/30 | Bardstown | 16 | 47 | L | 1 | Neutral | Louisville | Cardinal Stadium | John Derossett | championship at Louisville | |||
| 2002 | 11/8 | Estill County | 47 | 8 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2002 | 11/15 | Breathitt County | 24 | 42 | L | 1 | Away | Jackson | Mike Holcomb Athletic Complex | John Derossett | playoff at Jackson | |||
| 2003 | 11/7 | Breathitt County | 0 | 1 | L | 1 | Away | Jackson | Mike Holcomb Athletic Complex | John Derossett | playoff - forfeit - original score 19-7 | |||
| 2003 | 11/14 | Belfry | 19 | 27 | L | 1 | Away | Belfry | Al Vipperman Stadium | John Derossett | playoff at Belfry | |||
| 2004 | 11/5 | Leslie County | 36 | 0 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2004 | 11/12 | Breathitt County | 40 | 29 | W | 1 | Away | Jackson | Mike Holcomb Athletic Complex | John Derossett | playoff at Jackson | |||
| 2004 | 11/19 | Belfry | 12 | 28 | L | 1 | Away | Belfry | Al Vipperman Stadium | John Derossett | playoff at Belfry | |||
| 2005 | 11/4 | Middlesboro | 20 | 40 | L | 1 | Away | Middlesboro | Bradner Stadium | John Derossett | playoff at Middlesboro | |||
| 2006 | 11/3 | Sheldon Clark | 35 | 6 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2006 | 11/10 | Belfry | 10 | 35 | L | 1 | Away | Belfry | CAM Stadium | John Derossett | playoff at Belfry | |||
| 2007 | 11/9 | Morgan County | 70 | 6 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2007 | 11/16 | Shelby Valley | 38 | 0 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2007 | 11/23 | DeSales | 20 | 33 | L | 1 | Away | Louisville | Manuel | John Derossett | playoff at Louisville | |||
| 2008 | 11/7 | Perry County Central | 21 | 20 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2008 | 11/14 | Knott Central | 55 | 8 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2008 | 11/21 | Middlesboro | 20 | 7 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2008 | 11/28 | Corbin | 7 | 20 | L | 1 | Away | Corbin | Campbell Field | John Derossett | playoff at Corbin | |||
| 2009 | 11/6 | Knott Central | 56 | 8 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2009 | 11/13 | Middlesboro | 61 | 20 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2009 | 11/20 | Corbin | 23 | 7 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2009 | 11/27 | DeSales | 28 | 33 | L | 1 | Neutral | Louisville | Southern High | John Derossett | playoff at Louisville | |||
| 2010 | 11/5 | Knott Central | 66 | 0 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2010 | 11/12 | Middlesboro | 40 | 6 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2010 | 11/19 | Corbin | 14 | 48 | L | 1 | Away | Corbin | Campbell Field | John Derossett | playoff at Corbin | |||
| 2011 | 11/4 | Danville | 16 | 32 | L | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2012 | 11/2 | Middlesboro | 36 | 33 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2012 | 11/9 | Danville | 14 | 16 | L | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2013 | 11/8 | Lexington Christian | 36 | 15 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2013 | 11/15 | Danville | 20 | 13 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2013 | 11/22 | Somerset | 21 | 28 | L | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2014 | 11/7 | Middlesboro | 29 | 7 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2014 | 11/14 | Danville | 40 | 23 | W | 1 | Away | Danville | Admiral Stadium | John Derossett | playoff at Danville | |||
| 2014 | 11/21 | Shelby Valley | 14 | 20 | L | 1 | Away | Robinson Creek | John Derossett | playoff at Robinson Creek | ||||
| 2015 | 11/6 | Lexington Christian | 13 | 34 | L | 1 | Away | Lexington | John Derossett | playoff at Lexington | ||||
| 2016 | 11/4 | Somerset | 6 | 35 | L | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2017 | 11/3 | Middlesboro | 35 | 14 | W | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2017 | 11/10 | Lexington Christian | 12 | 42 | L | 1 | Home | Prestonsburg | Josh Francis Field | John Derossett | playoff at Prestonsburg | |||
| 2018 | 11/2 | Lexington Christian | 14 | 46 | L | 1 | Away | Lexington | Brandon Brewer | playoff at Lexington | ||||
| 2020 | 11/20 | West Carter | 6 | 36 | L | 1 | Away | Olive Hill | Michael Ed Blankenship Field | Brandon Brewer | playoff at Olive Hill | |||
| 2022 | 11/4 | Middlesboro | 30 | 42 | L | 1 | Away | Middlesboro | Bradner Stadium | Brandon Brewer | playoff at Middlesboro | |||
| 2023 | 11/3 | Betsy Layne | 7 | 21 | L | 1 | Away | Betsy Layne | Brandon Brewer | playoff at Betsy Layne | ||||
| 2024 | 11/8 | East Ridge | 39 | 8 | W | 1 | Home | Prestonsburg | Josh Francis Field | Wesley Hager | playoff at Prestonsburg | |||
| 2024 | 11/15 | Betsy Layne | 29 | 0 | W | 1 | Home | Prestonsburg | Josh Francis Field | Wesley Hager | playoff at Prestonsburg | |||
| 2024 | 11/22 | Somerset | 6 | 23 | L | 1 | Home | Prestonsburg | Josh Francis Field | Wesley Hager | playoff at Prestonsburg | |||
| 2025 | 11/7 | East Ridge | 48 | 21 | W | 1 | Home | Prestonsburg | Josh Francis Field | Wesley Hager | playoff at Prestonsburg | |||
| 2025 | 11/14 | Knott Central | 55 | 6 | W | 1 | Home | Prestonsburg | Josh Francis Field | Wesley Hager | playoff at Prestonsburg | |||
| 2025 | 11/21 | Beechwood | 0 | 42 | L | 1 | Away | Fort Mitchell | Edgar McNabb Field | Wesley Hager | playoff at Fort Mitchell | |||
| 2,191 | 1,833 | 46 | 42 | 0 | .523 | |||||||||
| 24.90 | 20.83 | 4.07 | ||||||||||||