| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1960 | 9/9 | DeSales | 27 | 7 | W | 1 | Home | Lexington | Roy Walton | ||||||
| 1961 | 9/8 | DeSales | 12 | 27 | L | 1 | Home | Lexington | Roy Walton | ||||||
| 1962 | 9/7 | DeSales | 35 | 19 | W | 1 | Home | Lexington | Roy Walton | ||||||
| 2023 | 9/8 | DeSales | 6 | 45 | L | 1 | Home | Lexington | James D. Ishmael Stadium | Jon Lawson | |||||
| 2024 | 9/13 | DeSales | 14 | 17 | L | 1 | Away | Louisville | Jon Lawson | ||||||
| 94 | 115 | 2 | 3 | 0 | .400 | ||||||||||
| 18.80 | 23.00 | -4.20 | |||||||||||||