| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1942 | 10/16 | Louisville St. Xavier, KY | 6 | 18 | L | 1 | Away | Louisville | Matt Thernes | ||||||
| 1945 | 10/21 | Louisville St. Xavier, KY | 19 | 14 | W | 1 | Away | Louisville | Du Pont Memorial Stadium | Charley O' Leary | |||||
| 1947 | 10/5 | Louisville St. Xavier, KY | 0 | 7 | L | 1 | Away | Louisville | Emmett Crowe | ||||||
| 1948 | 9/24 | Louisville St. Xavier, KY | 19 | 12 | W | 1 | Away | Louisville | Emmett Crowe | ||||||
| 1953 | 10/24 | Louisville St. Xavier, KY | 7 | 13 | L | 1 | Home | Cincinnati | Trechter Stadium | Walter Ornella | |||||
| 1954 | 10/23 | Louisville St. Xavier, KY | 14 | 20 | L | 1 | Away | Louisville | Bron Bacevich | ||||||
| 1955 | 10/7 | Louisville St. Xavier, KY | 7 | 7 | T | 1 | Home | Cincinnati | Bron Bacevich | ||||||
| 1956 | 10/6 | Louisville St. Xavier, KY | 0 | 0 | T | 1 | Away | Louisville | Bron Bacevich | ||||||
| 1957 | 10/4 | Louisville St. Xavier, KY | 0 | 9 | L | 1 | Home | Cincinnati | Bron Bacevich | ||||||
| 1958 | 10/4 | Louisville St. Xavier, KY | 26 | 13 | W | 1 | Away | Louisville | Bron Bacevich | ||||||
| 98 | 113 | 3 | 5 | 2 | .400 | ||||||||||
| 9.80 | 11.30 | -1.50 |