| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1919 | Louisville | L | 1 | Home | Minerva | ||||||||||
| 1921 | Louisville | W | 1 | R. E. Trachsel | |||||||||||
| 1924 | 11/21 | Louisville | 0 | 13 | L | 1 | Away | Louisville | |||||||
| 1925 | 10/30 | Louisville | 8 | 12 | L | 1 | Away | Louisville | DeWitt | ||||||
| 1926 | 10/29 | Louisville | 0 | 6 | L | 1 | Home | Minerva | Dietrich | ||||||
| 1927 | 11/11 | Louisville | 0 | 13 | L | 1 | Away | Louisville | A. Peterka | ||||||
| 1928 | 11/9 | Louisville | 7 | 13 | L | 1 | Away | Louisville | J. E. Shallcross | ||||||
| 1929 | 11/8 | Louisville | 6 | 6 | T | 1 | Away | Louisville | J. E. Shallcross | ||||||
| 1930 | 11/11 | Louisville | 12 | 0 | W | 1 | Away | Louisville | James McBride | ||||||
| 1931 | 11/11 | Louisville | 19 | 7 | W | 1 | Away | Louisville | James McBride | ||||||
| 1932 | 11/11 | Louisville | 37 | 0 | W | 1 | Home | Minerva | James McBride | ||||||
| 1933 | 11/11 | Louisville | 0 | 12 | L | 1 | Away | Louisville | James McBride | ||||||
| 1934 | 11/10 | Louisville | 0 | 8 | L | 1 | Home | Minerva | James McBride | ||||||
| 1935 | 11/11 | Louisville | 13 | 6 | W | 1 | Away | Louisville | James McBride | ||||||
| 1936 | 11/11 | Louisville | 19 | 6 | W | 1 | Home | Minerva | Lester Emerson | ||||||
| 1937 | 11/11 | Louisville | 12 | 7 | W | 1 | Away | Louisville | Lester Emerson | ||||||
| 1938 | 11/11 | Louisville | 0 | 6 | L | 1 | Home | Minerva | Lester Emerson | ||||||
| 1939 | 11/11 | Louisville | 20 | 0 | W | 1 | Away | Louisville | James McBride | ||||||
| 1940 | 11/11 | Louisville | 0 | 0 | T | 1 | Home | Minerva | James McBride | ||||||
| 1941 | 11/11 | Louisville | 6 | 7 | L | 1 | Away | Louisville | James McBride | ||||||
| 1942 | 11/11 | Louisville | 7 | 21 | L | 1 | Home | Minerva | |||||||
| 1943 | 11/11 | Louisville | 6 | 14 | L | 1 | Away | Louisville | Lester Emerson | ||||||
| 1944 | 11/11 | Louisville | 14 | 16 | L | 1 | Home | Minerva | Lester Emerson | ||||||
| 1945 | 11/12 | Louisville | 12 | 27 | L | 1 | Away | Louisville | Jerry O'Hara | ||||||
| 1946 | 11/11 | Louisville | 0 | 13 | L | 1 | Home | Minerva | Jerry O'Hara | ||||||
| 1947 | 11/11 | Louisville | 0 | 25 | L | 1 | Away | Louisville | Jerry O'Hara | ||||||
| 1948 | 11/11 | Louisville | 7 | 41 | L | 1 | Home | Minerva | John Canfield | ||||||
| 1949 | 11/11 | Louisville | 0 | 73 | L | 1 | Away | Louisville | Charles Catanese | ||||||
| 1950 | 11/11 | Louisville | 0 | 23 | L | 1 | Home | Minerva | Charles Catanese | ||||||
| 1951 | 11/9 | Louisville | 12 | 19 | L | 1 | Away | Louisville | Houston Schlosser | ||||||
| 1952 | 11/7 | Louisville | 20 | 7 | W | 1 | Home | Minerva | Herb Gordy | ||||||
| 1953 | 11/13 | Louisville | 14 | 19 | L | 1 | Away | Louisville | |||||||
| 1954 | 11/12 | Louisville | 0 | 6 | L | 1 | Home | Minerva | Don Lauther | ||||||
| 1955 | 11/12 | Louisville | 0 | 27 | L | 1 | Away | Louisville | Don Campbell | ||||||
| 1956 | 11/9 | Louisville | 6 | 6 | T | 1 | Home | Minerva | Don Campbell | ||||||
| 1957 | 11/8 | Louisville | 0 | 32 | L | 1 | Away | Louisville | Jim Paulet | ||||||
| 1958 | 11/7 | Louisville | 6 | 16 | L | 1 | Home | Minerva | Jim Paulet | ||||||
| 1959 | 11/13 | Louisville | 0 | 0 | T | 1 | Away | Louisville | Glenn Sutherin | ||||||
| 1960 | 11/11 | Louisville | 20 | 8 | W | 1 | Home | Minerva | Glenn Sutherin | ||||||
| 1961 | 11/10 | Louisville | 14 | 8 | W | 1 | Away | Louisville | Glenn Sutherin | ||||||
| 1962 | 11/9 | Louisville | 0 | 0 | T | 1 | Home | Minerva | Glenn Sutherin | ||||||
| 1963 | 11/8 | Louisville | 6 | 8 | L | 1 | Away | Louisville | Glenn Sutherin | ||||||
| 1964 | 11/13 | Louisville | 0 | 28 | L | 1 | Home | Minerva | Tom George | ||||||
| 1965 | 11/12 | Louisville | 0 | 62 | L | 1 | Away | Louisville | Tom Walters | ||||||
| 1966 | 11/11 | Louisville | 0 | 20 | L | 1 | Home | Minerva | Tom Walters | ||||||
| 1967 | 11/10 | Louisville | 12 | 6 | W | 1 | Away | Louisville | Tom Walters | ||||||
| 1968 | 11/8 | Louisville | 0 | 38 | L | 1 | Home | Minerva | Tom Walters | ||||||
| 1969 | 11/7 | Louisville | 18 | 6 | W | 1 | Away | Louisville | Tom Walters | ||||||
| 1970 | 11/13 | Louisville | 6 | 12 | L | 1 | Home | Minerva | Tom Walters | ||||||
| 1971 | 11/12 | Louisville | 0 | 25 | L | 1 | Away | Louisville | Tom Walters | ||||||
| 1972 | 11/10 | Louisville | 21 | 26 | L | 1 | Home | Minerva | Tom Walters | ||||||
| 1973 | 11/9 | Louisville | 8 | 29 | L | 1 | Away | Louisville | Tom Walters | ||||||
| 1974 | 11/8 | Louisville | 20 | 26 | L | 1 | Home | Minerva | Tom Walters | ||||||
| 1975 | 11/7 | Louisville | 8 | 60 | L | 1 | Away | Louisville | Garth Evans | ||||||
| 1976 | 11/12 | Louisville | 6 | 16 | L | 1 | Home | Minerva | Garth Evans | ||||||
| 1977 | 11/11 | Louisville | 12 | 14 | L | 1 | Away | Louisville | Garth Evans | ||||||
| 1978 | 9/1 | Louisville | 0 | 6 | L | 1 | Home | Minerva | Garth Evans | ||||||
| 1979 | 8/31 | Louisville | 14 | 23 | L | 1 | Away | Louisville | Garth Evans | ||||||
| 1980 | 8/29 | Louisville | 0 | 42 | L | 1 | Home | Minerva | Garth Evans | ||||||
| 1981 | 9/4 | Louisville | 8 | 21 | L | 1 | Away | Louisville | Fred Johnson | ||||||
| 1982 | 9/3 | Louisville | 0 | 28 | L | 1 | Home | Minerva | Fred Johnson | ||||||
| 1983 | 9/2 | Louisville | 0 | 21 | L | 1 | Away | Louisville | Fred Johnson | ||||||
| 1988 | 11/4 | Louisville | 50 | 6 | W | 1 | Away | Louisville | Lynn Molen | ||||||
| 1989 | 10/27 | Louisville | 38 | 0 | W | 1 | Home | Minerva | Lynn Molen | ||||||
| 1990 | 10/26 | Louisville | 16 | 36 | L | 1 | Home | Minerva | Fred Johnson | ||||||
| 1991 | 11/1 | Louisville | 0 | 24 | L | 1 | Away | Louisville | Fred Johnson | ||||||
| 1992 | 11/6 | Louisville | 20 | 43 | L | 1 | Home | Minerva | Lynn Molen | ||||||
| 1993 | 11/5 | Louisville | 26 | 27 | L | 1 | Away | Louisville | Lynn Molen | ||||||
| 1994 | 11/4 | Louisville | 29 | 37 | L | 1 | Home | Minerva | Lynn Molen | ||||||
| 1995 | 11/3 | Louisville | 26 | 20 | W | 1 | 1OT | Away | Louisville | Lynn Molen | |||||
| 1996 | 11/1 | Louisville | 21 | 38 | L | 1 | Home | Minerva | Lynn Molen | ||||||
| 1997 | 10/31 | Louisville | 35 | 7 | W | 1 | Away | Louisville | Lynn Molen | ||||||
| 1998 | 11/6 | Louisville | 47 | 15 | W | 1 | Home | Minerva | Dr. Robert Hines Stadium | Lynn Molen | |||||
| 1999 | 10/29 | Louisville | 27 | 21 | W | 1 | Home | Minerva | Dr. Robert Hines Stadium | Butch Wood | |||||
| 2000 | 10/27 | Louisville | 27 | 9 | W | 1 | Away | Louisville | Butch Wood | ||||||
| 2001 | 10/26 | Louisville | 6 | 20 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Butch Wood | |||||
| 2002 | 10/25 | Louisville | 0 | 27 | L | 1 | Away | Louisville | Alex Albert | ||||||
| 2003 | 10/24 | Louisville | 22 | 35 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Alex Albert | |||||
| 2004 | 10/29 | Louisville | 0 | 28 | L | 1 | Away | Louisville | Alex Albert | ||||||
| 2005 | 10/28 | Louisville | 7 | 48 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Brett Yeagley | |||||
| 2006 | 10/27 | Louisville | 6 | 58 | L | 1 | Away | Louisville | Brett Yeagley | ||||||
| 2007 | 10/26 | Louisville | 0 | 40 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Brett Yeagley | |||||
| 2008 | 10/24 | Louisville | 0 | 27 | L | 1 | Away | Louisville | Brett Yeagley | ||||||
| 2009 | 10/30 | Louisville | 7 | 25 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Brett Yeagley | |||||
| 2010 | 10/29 | Louisville | 20 | 42 | L | 1 | Away | Louisville | Brett Yeagley | ||||||
| 2011 | 9/23 | Louisville | 29 | 26 | W | 1 | Home | Minerva | Dr. Robert Hines Stadium | Dale Soles | |||||
| 2012 | 9/21 | Louisville | 14 | 35 | L | 1 | Away | Louisville | Dale Soles | ||||||
| 2013 | 10/11 | Louisville | 7 | 31 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Mike Hall | |||||
| 2014 | 10/10 | Louisville | 21 | 44 | L | 1 | Away | Louisville | Mike Hall | ||||||
| 2015 | 9/25 | Louisville | 0 | 48 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Mike Hall | |||||
| 2016 | 9/23 | Louisville | 0 | 53 | L | 1 | Away | Louisville | Lance Willison | ||||||
| 2017 | 9/29 | Louisville | 7 | 45 | L | 1 | Home | Minerva | Dr. Robert Hines Stadium | Lance Willison | |||||
| 944 | 1,955 | 21 | 66 | 5 | .255 | ||||||||||
| 10.49 | 21.72 | -11.23 |