| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes |
| 1916 | 10/20 | North Lewisburg | 0 | 1 | L | 1 | Away | North Lewisburg | Mechanicsburg left the field tied 0-0 | |||||
| 1917 | 9/24 | North Lewisburg | 27 | 13 | W | 1 | Away | North Lewisburg | ||||||
| 1917 | 10/26 | North Lewisburg | 90 | 0 | W | 1 | Home | Mechanicsburg | ||||||
| 1917 | 11/16 | North Lewisburg | 7 | 14 | L | 1 | Away | North Lewisburg | ||||||
| 1919 | 10/3 | North Lewisburg | 7 | 27 | L | 1 | Away | North Lewisburg | ||||||
| 1921 | 10/21 | North Lewisburg | 0 | 20 | L | 1 | Home | Mechanicsburg | ||||||
| 1922 | 9/22 | North Lewisburg | 12 | 7 | W | 1 | Home | Mechanicsburg | ||||||
| 1922 | 10/27 | North Lewisburg | 6 | 27 | L | 1 | Away | North Lewisburg | ||||||
| 1923 | 10/19 | North Lewisburg | ||||||||||||
| 1923 | 11/1 | North Lewisburg | 14 | 0 | W | 1 | Away | North Lewisburg | ||||||
| 1924 | 11/14 | North Lewisburg | 37 | 0 | W | 1 | Away | North Lewisburg | ||||||
| 1929 | 9/27 | North Lewisburg | 26 | 13 | W | 1 | Home | Mechanicsburg | Dave Wing | |||||
| 226 | 122 | 6 | 5 | 0 | .545 | |||||||||
| 20.55 | 11.09 | 9.45 |