| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1934 | 9/22 | Louisville | 28 | 2 | W | 1 | Away | Louisville | Perry Van Hyning | ||||||
| 1935 | 9/21 | Louisville | 12 | 6 | W | 1 | Home | East Palestine | Perry Van Hyning | ||||||
| 1936 | 9/19 | Louisville | 13 | 7 | W | 1 | Away | Louisville | Perry Van Hyning | ||||||
| 1937 | 9/18 | Louisville | 0 | 0 | T | 1 | Home | East Palestine | Perry Van Hyning | ||||||
| 1938 | 9/17 | Louisville | 0 | 19 | L | 1 | Away | Louisville | Howard Parker | ||||||
| 1939 | 9/15 | Louisville | 13 | 0 | W | 1 | Home | East Palestine | Howard Parker | ||||||
| 1940 | 11/16 | Louisville | 0 | 28 | L | 1 | Away | Louisville | Howard Parker | ||||||
| 1941 | 11/15 | Louisville | 0 | 18 | L | 1 | Home | East Palestine | Howard Parker | ||||||
| 1942 | 11/14 | Louisville | 0 | 21 | L | 1 | Away | Louisville | Howard Parker | ||||||
| 1943 | 11/5 | Louisville | 13 | 7 | W | 1 | Home | East Palestine | Howard Parker | ||||||
| 1944 | 11/4 | Louisville | 12 | 7 | W | 1 | Away | Louisville | John Reid | ||||||
| 1945 | 11/2 | Louisville | 6 | 58 | L | 1 | Home | East Palestine | Bob Akenhead | ||||||
| 1946 | 11/1 | Louisville | 20 | 6 | W | 1 | Away | Louisville | Howard Parker | ||||||
| 1947 | 10/31 | Louisville | 13 | 7 | W | 1 | Home | East Palestine | Howard Parker | ||||||
| 1948 | 11/5 | Louisville | 0 | 65 | L | 1 | Away | Louisville | Howard Parker | ||||||
| 1949 | 11/4 | Louisville | 0 | 21 | L | 1 | Home | East Palestine | Howard Parker | ||||||
| 1950 | 11/3 | Louisville | 6 | 26 | L | 1 | Away | Louisville | Howard Parker | ||||||
| 1951 | 11/2 | Louisville | 13 | 6 | W | 1 | Home | East Palestine | Ken Meyer | ||||||
| 1952 | 10/31 | Louisville | 46 | 25 | W | 1 | Away | Louisville | John Hogan | ||||||
| 1953 | 11/6 | Louisville | 27 | 7 | W | 1 | Home | East Palestine | John Hogan | ||||||
| 1954 | 11/5 | Louisville | 7 | 0 | W | 1 | Away | Louisville | John Hogan | ||||||
| 1955 | 11/5 | Louisville | 19 | 20 | L | 1 | Home | East Palestine | Bob Kelley | ||||||
| 1956 | 11/2 | Louisville | 42 | 6 | W | 1 | Away | Louisville | John Hogan | ||||||
| 1957 | 11/1 | Louisville | 20 | 0 | W | 1 | Home | East Palestine | John Hogan | ||||||
| 1958 | 10/31 | Louisville | 28 | 22 | W | 1 | Away | Louisville | Bill Mallory | ||||||
| 1959 | 11/6 | Louisville | 6 | 0 | W | 1 | Home | East Palestine | Howard Weyers | ||||||
| 1960 | 11/4 | Louisville | 30 | 6 | W | 1 | Away | Louisville | Howard Weyers | ||||||
| 1961 | 11/3 | Louisville | 8 | 22 | L | 1 | Home | East Palestine | Reid Memorial Stadium | Rey Dempsey | |||||
| 1962 | 11/2 | Louisville | 0 | 54 | L | 1 | Away | Louisville | Rey Dempsey | ||||||
| 1963 | 11/1 | Louisville | 6 | 28 | L | 1 | Home | East Palestine | Reid Memorial Stadium | Rey Dempsey | |||||
| 1964 | 11/6 | Louisville | 0 | 32 | L | 1 | Away | Louisville | Rey Dempsey | ||||||
| 1965 | 11/5 | Louisville | 0 | 51 | L | 1 | Home | East Palestine | Reid Memorial Stadium | Bill Offenbecher | |||||
| 1966 | 11/4 | Louisville | 0 | 42 | L | 1 | Away | Louisville | Bill Offenbecher | ||||||
| 388 | 619 | 17 | 15 | 1 | .530 | ||||||||||
| 11.76 | 18.76 | -7.00 | |||||||||||||