| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1920 | 11/20 | Toledo Central Catholic | 0 | 6 | L | 1 | Home | Defiance | Central Field | J. R. Brandon | |||||
| 1921 | 10/1 | Toledo Central Catholic | 2 | 0 | W | 1 | Home | Defiance | Paul Bertschy | ||||||
| 1923 | 10/20 | Toledo Central Catholic | 0 | 20 | L | 1 | Away | Toledo | F. E. Treat | ||||||
| 2013 | 11/8 | Toledo Central Catholic | 14 | 69 | L | 1 | Away | Toledo | Gallagher Stadium | Jerry Buti | playoff at Toledo | ||||
| 2023 | 11/3 | Toledo Central Catholic | 26 | 41 | L | 1 | Away | Toledo | Gallagher Stadium | Travis Cooper | playoff at Toledo | ||||
| 42 | 136 | 1 | 4 | 0 | .200 | ||||||||||
| 8.40 | 27.20 | 18.80 | |||||||||||||