| Year | Date | Opponent | Us | Them | Result | W | L | T | OT | Where | Location | Field | Coach | Notes | |
| 1990 | 10/12 | Louisville | 6 | 28 | L | 1 | Away | Louisville | Dan Simon | ||||||
| 1991 | 10/18 | Louisville | 0 | 50 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Dan Simon | |||||
| 1992 | 10/23 | Louisville | 6 | 47 | L | 1 | Away | Louisville | Dan Simon | ||||||
| 1993 | 10/22 | Louisville | 0 | 23 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Dan Simon | |||||
| 1994 | 10/21 | Louisville | 2 | 42 | L | 1 | Away | Louisville | Joe Schultz | ||||||
| 1995 | 10/20 | Louisville | 7 | 62 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Joe Schultz | |||||
| 1996 | 10/18 | Louisville | 0 | 19 | L | 1 | Away | Louisville | Joe Schultz | ||||||
| 1997 | 10/17 | Louisville | 0 | 26 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Steve Masten | |||||
| 1998 | 10/23 | Louisville | 23 | 53 | L | 1 | Away | Louisville | Steve Masten | ||||||
| 1999 | 9/17 | Louisville | 9 | 36 | L | 1 | Away | Louisville | Vic Whiting | ||||||
| 2000 | 9/15 | Louisville | 9 | 16 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Vic Whiting | |||||
| 2001 | 9/21 | Louisville | 10 | 0 | W | 1 | Away | Louisville | Vic Whiting | ||||||
| 2002 | 9/20 | Louisville | 7 | 21 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Vic Whiting | |||||
| 2003 | 9/26 | Louisville | 19 | 0 | W | 1 | Away | Louisville | Vic Whiting | ||||||
| 2004 | 10/1 | Louisville | 12 | 9 | W | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Vic Whiting | |||||
| 2005 | 10/7 | Louisville | 0 | 14 | L | 1 | Away | Louisville | Vic Whiting | ||||||
| 2006 | 10/6 | Louisville | 14 | 13 | W | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Vic Whiting | |||||
| 2007 | 9/14 | Louisville | 34 | 33 | W | 1 | Away | Louisville | Vic Whiting | ||||||
| 2008 | 9/12 | Louisville | 7 | 33 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Vic Whiting | |||||
| 2009 | 9/25 | Louisville | 15 | 23 | L | 1 | Away | Louisville | Vic Whiting | ||||||
| 2010 | 9/24 | Louisville | 14 | 39 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | Vic Whiting | |||||
| 2022 | 9/2 | Louisville | 6 | 16 | L | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | John DeMarco | |||||
| 2023 | 9/1 | Louisville | 26 | 14 | W | 1 | Away | Louisville | John DeMarco | ||||||
| 2024 | 9/6 | Louisville | 35 | 28 | W | 1 | Home | Canal Fulton | Dr. Martin Smilek Stadium | John DeMarco | |||||
| 2025 | 9/5 | Louisville | 3 | 10 | L | 1 | Away | Louisville | John DeMarco | ||||||
| 264 | 655 | 7 | 18 | 0 | .280 | ||||||||||
| 10.56 | 26.20 | 15.64 | |||||||||||||